HP1 is recruited to regions in which histone H3 has been methylated at lysine 9, a modification involved in heterochromatin formation. It turns out that HP1 can also interact with Dnmt1, which can promote DNA methylation in the vicinity of HP1 binding. Furthermore, Dnmt1 can directly interact with the methyltransferase responsible for H3K9 methylation, creating a positive feedback loop to ensure continued DNA and histone methylation.
#Unit 3. Fundamental Processes#Chromatin Remodelling & Epigenetics#Part B Pointers
