Negative costimulation

TLS Online TPP Program

#Id: 2978

#Unit 3. Fundamental Processes

This alteration to the structure of the chromosome is accomplished by the enzyme topoisomerase. Replication cannot occur on supercoiled DNA, only the relaxed form.

TLS Online TPP Program

#Id: 2979

#Unit 3. Fundamental Processes

The replisome exists only as a protein complex associated with the particular structure that DNA takes at the replication fork.

TLS Online TPP Program

#Id: 2980

#Unit 3. Fundamental Processes

It does not exist as an independent unit (e.g., analogous to the ribosome), but assembles de novo at the origin for each replication cycle.

TLS Online TPP Program

#Id: 2981

#Unit 3. Fundamental Processes

DNA is synthesized in both semiconservative replication and repair reactions.

TLS Online TPP Program

#Id: 2982

#Unit 3. Fundamental Processes

Only one DNA polymerase is the replication enzyme. The others participate in repair of damaged DNA, restarting stalled replication forks, or bypass 1ng damage in DNA.

TLS Online TPP Program

#Id: 2983

#Unit 3. Fundamental Processes

All prokaryotic and eukaryotic DNA polymerases share the same fundamental type of synthetic activity, antiparallel synthesis from 5' to 3' from a template that is 3' to 5'.