ACR harbours seven transmembrane domains and is embedded in the nuclear membrane of prestalk cells.

TLS Online TPP Program

#Id: 10383

#Unit 4. Cell Communication and Cell Signaling

Corticosteroids and prostaglandins can also decrease expression of class II MHC molecules.

TLS Online TPP Program

#Id: 10384

#Unit 4. Cell Communication and Cell Signaling

Class II MHC transcriptional activator called CIITA and another transcription factor called RFX, have both been shown to activate the promoter of class II MHC genes.

Defects in these transcription factors cause one form of bare lymphocyte syndrome.

TLS Online TPP Program

#Id: 10385

#Unit 4. Cell Communication and Cell Signaling

Cross-presentation

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#Id: 10386

#Unit 4. Cell Communication and Cell Signaling

Presentation of nonpeptide antigens derived from pathogens involves the nonclassical class I–like CD1 molecule

TLS Online TPP Program

#Id: 10387

#Unit 4. Cell Communication and Cell Signaling

Class I presentation requires internal synthesis of virus protein, as shown by the requirement that the target cell be infected by live virus, and by the inhibition of class I presentation observed when protein synthesis was blocked by the inhibitor emetine.

TLS Online TPP Program

#Id: 10388

#Unit 4. Cell Communication and Cell Signaling

Class II presentation can occur with either live or replication-incompetent virus; protein synthesis inhibitors had no effect, indicating that new protein synthesis is not a necessary condition of class II presentation.