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TLS Online TPP Program

#Id: 7472

The two β pleated sheets in each domain are held together by hydrophobic interactions and the conserved disulfide bond.  The three loops of each variable domain show considerable variation in length and amino acid sequence; these hyper variable regions  make up the antigen-binding site. 



#Unit 4. Cell Communication and Cell Signaling #Antibody #Part B Pointers
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TLS Online TPP Program

#Id: 8605

#Unit 2. Cellular Organization

S phase Cyclin–CDKs
In human - cyclin A-CDK 2 
In budding yeast - CIb 5/6-Cdc 28
TLS Online TPP Program

#Id: 8606

#Unit 2. Cellular Organization

M phase Cyclin–CDKs
In human - cyclin A-CDK 1
cyclin B-CDK 1
In budding yeast - CIb 1/2/3/4-Cdc 28
TLS Online TPP Program

#Id: 8607

#Unit 2. Cellular Organization

Cdk1 
=Cdc2 (vertebrates and fission yeast)
= Cdc28  (budding yeast)
TLS Online TPP Program

#Id: 8608

#Unit 2. Cellular Organization

There are three D cyclins in mammals:
cyclins D1, D2, and D3
TLS Online TPP Program

#Id: 8609

#Unit 2. Cellular Organization

In free CDK2, the A-loop blocks access of protein substrates to the γ phosphate of the bound ATP.
TLS Online TPP Program

#Id: 8610

#Unit 2. Cellular Organization