𝝅-Turn

Consists of 6 amino acids, generally termed as i, i + 1 , i + 2 i + 3 i + 4 and i + 5

H-bond is seen between i and i + 5 (First and sixth residue)

TLS Online TPP Program

#Id: 1270

#Unit 7. System Physiology – Animal

Negative feedback is exerted by cortisol in the hypothalamic-pituitary axis.

TLS Online TPP Program

#Id: 1271

#Unit 7. System Physiology – Animal

The zona glomerulosa is controlled via; Renin-angiotensin-aldosterone system. 

TLS Online TPP Program

#Id: 1272

#Unit 7. System Physiology – Animal

Aldosterone has three actions on the late distal tubule and collecting ducts of the kidney: 

Increases Na+ reabsorption

Increases K+ secretion

Increases H+ secretion

TLS Online TPP Program

#Id: 1273

#Unit 7. System Physiology – Animal

ACTH stimulates the synthesis and secretion of cortisol by the activation of adenylyl cyclase via Gs.

TLS Online TPP Program

#Id: 1274

#Unit 7. System Physiology – Animal

Angiotensin II stimulates the synthesis and secretion of aldosterone by the activation of phospholipase C via Gq. 

TLS Online TPP Program

#Id: 1275

#Unit 7. System Physiology – Animal

Important effect of cortisol, Decrease translocation of GLUT4 to the cell membrane.