Normal GHB values are about 5% of total hemoglobin. In people with untreated diabetes, value may be as high as 13%

TLS Online TPP Program

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#Unit 4. Cell Communication and Cell Signaling

Chronic myelogenous leukemia, 

a common leukemia in humans, associated with the Philadelphia chromosome

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#Id: 10456

#Unit 4. Cell Communication and Cell Signaling

A highly specific inhibitor imatinib (Gleevec), which

binds directly to the active site of the ABL kinase and holds it in an inactive conformation to inhibit its kinase activity, is lethal to CML cells

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#Unit 4. Cell Communication and Cell Signaling

TLS Online TPP Program

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#Unit 4. Cell Communication and Cell Signaling

Inappropriate production of nuclear transcription factors such as FOS, JUN, and MYC can induce transformation.

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#Id: 10460

#Unit 4. Cell Communication and Cell Signaling

Burkitt’s lymphoma

translocation between chromosomes 8 and 14

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#Id: 10461

#Unit 4. Cell Communication and Cell Signaling

In Burkitt’s lymphoma cells, 

MYC is translocated close to an antibody gene, leading to overproduction of MYC