Matrix-targeting sequences

Located at the N-terminus

Usually 20–50 amino acids in length

Rich in hydrophobic amino acids, positively charged basic amino acids (arginine & lysine), and hydroxylated ones (serine and threonine)

Amphipathicity of matrix-targeting sequences is critical to their function

TLS Online TPP Program

#Id: 682

#Unit 3. Fundamental Processes

Cdc13 binds to the single-stranded telomere repeat DNA and is involved in telomerase recruitment.

TLS Online TPP Program

#Id: 683

#Unit 3. Fundamental Processes

POT1 binding to single-stranded telomere DNA inhibits telomere activity.

TLS Online TPP Program

#Id: 684

#Unit 3. Fundamental Processes

Structure of growing Telomere is potential target for DSBR

TLS Online TPP Program

#Id: 685

#Unit 3. Fundamental Processes

Attempts to repair telomeres in the DSBR manner as double-stranded DNA breaks would lead to chromosome fusion events, which eventually result in random chromosome breaks.

TLS Online TPP Program

#Id: 686

#Unit 3. Fundamental Processes

 Shelterin proteins bound at the telomere distinguish telomeres from other DNA ends in the cell prevents telomeres from normal DSBR

TLS Online TPP Program

#Id: 687

#Unit 3. Fundamental Processes

Elimination of Shelterin leads to the recognition of the telomeres as normal DNA breaks.