Cardiolipin

an unusual “double” phospholipid containing four fatty acid chains

found primarily in the inner mitochondrial membrane

acts to improve the efficiency of oxidative phosphorylation, by restricting proton flow across the membrane

#Id: 697

#Unit 3. Fundamental Processes

Substitutions occurs when Proofreading fails

#Id: 698

#Unit 3. Fundamental Processes

Frameshifts occurs when Processivity fails

#Id: 699

#Unit 3. Fundamental Processes

Frameshifts normally occurs homopolymeric sequences as long sequence of dTn:dAn

#Id: 700

#Unit 3. Fundamental Processes

As a general rule, increased processivity reduces the likelihood of slippage at long sequence of dTn:dAn or frameshift mutation 

#Id: 701

#Unit 3. Fundamental Processes

#Id: 702

#Unit 3. Fundamental Processes

The replicase activity of DNA polymerase III was originally discovered by a conditional lethal mutation in the dnaE locus, which codes for the 130 kD, a subunit that possesses the DNA synthetic activity.