The two key components in protein targeting in ER:

Signal recognition particle (SRP)

SRP receptor

TLS Online TPP Program

#Id: 3863

#Unit 5. Developmental Biology

Ammonia inhibits PKA by indirectly activating cAMP hydrolysis via DhkC-RdeA mediated phosphorylation of RegA.

TLS Online TPP Program

#Id: 3864

#Unit 5. Developmental Biology

High PSF to food ratio is upregulate the translation of the PKA catalytic subunit PKA-C.

TLS Online TPP Program

#Id: 3865

#Unit 5. Developmental Biology

A second glycoprotein secreted during starvation is CMF (conditioned medium factor)

TLS Online TPP Program

#Id: 3866

#Unit 5. Developmental Biology

Histidine phosphatase activity of DhkA causes inactivation of RegA, the accumulation of cAMP and PKA activation, causes spore maturation.

TLS Online TPP Program

#Id: 3867

#Unit 5. Developmental Biology

CMF stimulates gene expression in parallel with PSF, and both signals potentiate cAMP signaling by inducing genes involved in cAMP synthesis and detection

TLS Online TPP Program

#Id: 3868

#Unit 5. Developmental Biology

In prespore cells, PKA activation occurs by signalling cascade that is activated by SDF-3, which triggers the synthesis of GABA