In the bacterial genome, the minimum length of promoter that could provide an adequate signal is 12 bp.  The minimum length required for unique recognition increases with the size of genome, a problem in eukaryotic genomes.

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#Unit 3. Fundamental Processes

Telomerase protein component with catalytic activity is encoded by EST2 in yeast, hTERT in humans

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#Unit 3. Fundamental Processes

The RNA component is typically short 159 bases long in Tetrahymena, and 451 bases long in humans, though 1.3 kb in yeast

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#Unit 3. Fundamental Processes

EST proteins regulates number of repeats in RNA component for telomere lengths.

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#Unit 3. Fundamental Processes

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#Unit 3. Fundamental Processes

Cdc13 is a positive activator of telomerase

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#Unit 3. Fundamental Processes