The amino group at C-2 bears a fatty acid in amide linkage.

The fatty acid is usually saturated or monounsaturated, with 16, 18, 22, or 24 carbon atoms.

Ceramide is the parent compound for this group.

TLS Online TPP Program

#Id: 398

#Unit 2. Cellular Organization

Modification of histones is associated with replication and transcription, and specific modifications also facilitate DNA repair.

TLS Online TPP Program

#Id: 399

#Unit 2. Cellular Organization

Variants have been identified for all core histones except histone H4.

TLS Online TPP Program

#Id: 400

#Unit 2. Cellular Organization

MacroH2A is nearly three times larger than conventional H2A, and contains a large C-terminal tail that is not related to any other histone.

TLS Online TPP Program

#Id: 401

#Unit 2. Cellular Organization

Canonical H3 also known as H3.1 differs from the H3.3 variant at only four amino acid positions—three in the histone core and one in the N-terminal tail.

TLS Online TPP Program

#Id: 402

#Unit 2. Cellular Organization

Centromeric H3 (or CenH3) histone, known as Cse4 in yeast. CenH3 histones are incorporated into specialized nucleosomes present at centromeres.

TLS Online TPP Program

#Id: 403

#Unit 2. Cellular Organization

CenH3 has a unique N terminus, which does not resemble other core histones.