A consensus sequence is, in each case a version of the sequence having at each position the nucleotide (or amino acid) most commonly found. consensus sequence was derived by aligning 300 sequences known to function as s70 promoters and ascertaining the most common base found at each position in the –35 and –10 hexamers.

TLS Online TPP Program

#Id: 8626

#Unit 2. Cellular Organization

RBX1 is a RING finger–containing protein that binds the E2 ubiquitin-conjugating enzyme.

TLS Online TPP Program

#Id: 8627

#Unit 2. Cellular Organization

phosphoserine/threonine-binding F-box protein is Skp2, which uses a series of leucine-rich repeats to bind to target proteins only when they are phosphorylated.

TLS Online TPP Program

#Id: 8628

#Unit 2. Cellular Organization

APC/C consists of 14 core subunits in metazoans and 13 core subunits in yeast.

TLS Online TPP Program

#Id: 8629

#Unit 2. Cellular Organization

APC/C works with substrate-targeting factors called Cdc20 and Cdh1

TLS Online TPP Program

#Id: 8630

#Unit 2. Cellular Organization

TLS Online TPP Program

#Id: 8631

#Unit 2. Cellular Organization

APC/C core is organized into three modules: 

1. a scaffold module 

2. a catalytic module

3. a substrate recognition module