TLS Online TPP Program

#Id: 1690

#Unit 4. Cell Communication and Cell Signaling

Site of DNA cleavage- Recombination Signal Sequence (RSS) 

TLS Online TPP Program

#Id: 1691

#Unit 4. Cell Communication and Cell Signaling

TLS Online TPP Program

#Id: 1692

#Unit 4. Cell Communication and Cell Signaling

Recognition of Recombination Signal Sequence (RSS) by the RAG1/RAG2 enzyme complex.

TLS Online TPP Program

#Id: 1693

#Unit 4. Cell Communication and Cell Signaling

RAG1 is expressed at all phases of the cell cycle, RAG2 is stable only in G0- or G1-phase cells.

TLS Online TPP Program

#Id: 1694

#Unit 4. Cell Communication and Cell Signaling

Threonine residue T490 on RAG2 is phosphorylated during the S, G2, and M phases of the cell cycle, and this phosphorylation triggers the destruction of RAG2.

TLS Online TPP Program

#Id: 1695

#Unit 4. Cell Communication and Cell Signaling

RAG1 is the predominant recombinase; it forms a complex with the RSS that is stabilized by the binding of RAG2.

RAG2 by itself does not exhibit detectable RSS binding activity