The dissolution of nonpolar molecules in water is unfavourable because of the large decrease in entropy resulting from clathrate formation, even though the process is exothermic (dH < 0) But unfavourable dG > 0.
#Unit 1. Molecules and their Interaction Relevant to Biology#Stablizing interactions (Van der Waals, electrostatic, hydrogen bonding, hydrophobic interaction)#Part B Pointers
