One NPF is called WASp, as it is defective in patients with Wiskott-Aldrich syndrome.

TLS Online TPP Program

#Id: 8615

#Unit 2. Cellular Organization

Y15 & T14 are situated in the G-loop of the CDK, containing the consensus sequence GEGT14Y15GVV

TLS Online TPP Program

#Id: 8616

#Unit 2. Cellular Organization

Phosphorylation of T14 and Y15 in this G-loop

introduces negative charge that electrostatically interferes with the binding of ATP in the catalytic pocket.

TLS Online TPP Program

#Id: 8617

#Unit 2. Cellular Organization

Wee1 kinase Inhibits CDKs in all organisms

TLS Online TPP Program

#Id: 8618

#Unit 2. Cellular Organization

Cdc25 phosphatase Activates CDKs in fission yeast

TLS Online TPP Program

#Id: 8619

#Unit 2. Cellular Organization

INK4s

bind to CDK4 and CDK6 monomers, blocking their interaction with cyclin D

TLS Online TPP Program

#Id: 8620

#Unit 2. Cellular Organization

A second class of CKIs found in metazoan cells is the Cip/Kip family of CKIs, consists of three proteins—p21CIP, p27KIP1, and p57KIP2.