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TLS Online TPP Program

#Id: 8449

The first 4 amide hydrogens and the last 4 carbonyl oxygens cannot participate in helix H bonds.

#Unit 1. Molecules and their Interaction Relevant to Biology #Conformation of proteins #Part B Pointers
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TLS Online TPP Program

#Id: 8350

#Unit 2. Cellular Organization

One NPF is called WASp, as it is defective in patients with Wiskott-Aldrich syndrome.
TLS Online TPP Program

#Id: 8351

#Unit 2. Cellular Organization

WASp activation requires two signals (This type of two-signal input, called coincidence detection):
1. regulatory phospholipid PIP2
2. small GTP-binding protein Cdc42
TLS Online TPP Program

#Id: 8353

#Unit 2. Cellular Organization

A second NPF is a large protein complex called WAVE
and requires small GTP-binding protein Rac1.
TLS Online TPP Program

#Id: 8354

#Unit 2. Cellular Organization

Listeria is a food-borne bacterial pathogen has on its surface a protein ActA, which mimics an NPF that efficiently activates the Arp2/3 complex.
TLS Online TPP Program

#Id: 8356

#Unit 2. Cellular Organization

ActA protein binds the host protein VASP, which enhance actin assembly and confine it to the rear of the bacterium.
TLS Online TPP Program

#Id: 8357

#Unit 2. Cellular Organization

VASP 
has a proline-rich
hold onto the end of the newly formed filament
protect the end of the growing filament from CapZ