The central bond in this case is the peptide bond, where rotation is constrained. The peptide bond is normally (99.6% of the time) in the trans configuration, constraining  to a value of w=+_180. For a rare cis peptide bond, w=0.

TLS Online TPP Program

#Id: 1732

#Unit 4. Cell Communication and Cell Signaling

The early response occurs within minutes of allergen exposure and results from the release of histamine, leukotrienes, and prostaglandins from local mast cells.

TLS Online TPP Program

#Id: 1733

#Unit 4. Cell Communication and Cell Signaling

Eosinophils play a principal role in the late-phase reaction.

TLS Online TPP Program

#Id: 1734

#Unit 4. Cell Communication and Cell Signaling

There Are Several Categories of Type I Hypersensitivity Reactions

1. Systemic Anaphylaxis

2. Localized Hypersensitivity Reactions

TLS Online TPP Program

#Id: 1735

#Unit 4. Cell Communication and Cell Signaling

Diagnostic approach

1. Skin testing

2. Measure the serum levels of either total or allergen specific IgE using ELISA or Western blot technologies

TLS Online TPP Program

#Id: 1736

#Unit 4. Cell Communication and Cell Signaling

Antigen pieces are held within the binding groove of a cell surface protein called the major histocompatibility complex (MHC) molecule which recognized by T cell

TLS Online TPP Program

#Id: 1737

#Unit 4. Cell Communication and Cell Signaling

Class I MHC, glycoproteins expressed on the surface of nearly all nucleated cells; the major function of the class I is presentation of endogenous peptide antigens to CD8+ T cells.