TLS Online TPP Program

#Id: 10061

#Unit 4. Cell Communication and Cell Signaling

Trans interactions (intercellular or adhesive interactions)

CAMs on one cell bind to CAMs on an adjacent cell. 

TLS Online TPP Program

#Id: 10062

#Unit 4. Cell Communication and Cell Signaling

In cis interactions (intracellular or lateral interactions)

monomeric CAMs on one cell bind to one or more CAMs in the same cell’s plasma membrane

TLS Online TPP Program

#Id: 10063

#Unit 4. Cell Communication and Cell Signaling

CAMs fall into one of four major families: 

Cadherins

Immunoglobulin (Ig) superfamily

Integrins

Selectins

TLS Online TPP Program

#Id: 10064

#Unit 4. Cell Communication and Cell Signaling

The adhesiveness of cadherins depends on the presence of extracellular Ca2+

TLS Online TPP Program

#Id: 10065

#Unit 4. Cell Communication and Cell Signaling

Two type of Cadherins:

1. Classical cadherin proteins

2. Nonclassical cadherin proteins

TLS Online TPP Program

#Id: 10066

#Unit 4. Cell Communication and Cell Signaling

Extracellular region of a classical cadherin contains five copies of the cadherin domain separated by flexible hinge regions