Domain

Domains are formed by combinations of SS, SSS, motifs and connected by loops and turns.

Highly conversed and may be common in most unrelated proteins

They evolve

Can function Independently

Average 100 amino acids 

Single hydrophobic core

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B cell properties 

They are APCs

They can express MHC2

Have surface marker  CD19

Antibodies at surface of b cell – IgM, IgD

Part of Adaptive immunity 

B cell convert into plasma cell

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Surface protein on B cell

CR2(CR21)

CD19

TAPA-1(CD81)

mIg 

Igα/ Igβ

(CD79a and CD79B)

TLR

CD40

B7 (CD80/86)

ICAM-1

MHC-1 and 2

CD 22

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Formation of mature B-cell

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Progress through their developmental program

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#Unit 5. Developmental Biology

B-Cell Development