In skeletal muscle, 

The desmin filaments encircle the Z disk and are cross-linked to the plasma membrane. 

TLS Online TPP Program

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#Unit 3. Fundamental Processes

DnaA is in the active form only when bound to ATP.

TLS Online TPP Program

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#Unit 3. Fundamental Processes

Dna A has intrinsic ATPase activity that hydrolyzes ATP to ADP and thus inactivates itself when the initiation stage ends.

TLS Online TPP Program

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#Unit 3. Fundamental Processes

This ATPase activity of Dna A is stimulated by membrane phospholipids and single-stranded DNA.

TLS Online TPP Program

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#Unit 3. Fundamental Processes

The origin of the replication region remains attached to the membrane for about one-third of the cell cycle as another part of the mechanism to prevent reinitiation.

TLS Online TPP Program

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#Unit 3. Fundamental Processes

Opening oriC involves action at two types of sequence in the origin: 9-bp and 13 -bp repeats.

TLS Online TPP Program

#Id: 2903

#Unit 3. Fundamental Processes

The four 9-bp consensus sequences on the right side of oriC provide the initial binding sites for DnaA-ATP in an extended multimeric state promoted by the accessory protein DiaA, which stimulates cooperative binding of DnaA.