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TLS Online TPP Program

#Id: 8590

Mitotic CDKs drive phosphorylation of lamins A, B, and C results in disassembly of the intermediate filament lattice into lamin dimers.

#Unit 2. Cellular Organization #Intermediate Filaments #Part B Pointers
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TLS Online TPP Program

#Id: 9093

#Unit 4. Cell Communication and Cell Signaling

Ligand binding to GPCRs that activate Gαq, leading to activation of phospholipase C
TLS Online TPP Program

#Id: 9094

#Unit 4. Cell Communication and Cell Signaling

Phospholipase C cleaves a phospholipid known as PI(4,5) P2, generating two second messengers: 
diffusible IP3 and membrane-bound DAG
TLS Online TPP Program

#Id: 9095

#Unit 4. Cell Communication and Cell Signaling
TLS Online TPP Program

#Id: 9096

#Unit 4. Cell Communication and Cell Signaling

IP3 triggers the opening of IP3-gated Ca2+ channels in the ER and elevation of cytosolic free Ca2+.
TLS Online TPP Program

#Id: 9097

#Unit 4. Cell Communication and Cell Signaling

In response to elevated cytosolic Ca2+ 
PKC is recruited to the plasma membrane, where it is activated by DAG
TLS Online TPP Program

#Id: 9098

#Unit 4. Cell Communication and Cell Signaling

Glycogen breakdown and synthesis is coordinately regulated by the second messengers Ca2+ and cAMP, whose levels are regulated by neural and hormonal stimulation, respectively