Cyclins are degraded through the action of two different E3-ligases:

1. SCF (Skp1, Cullin, and F-box proteins) 

2. APC/C or cyclosome

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#Id: 7187

#Unit 5. Developmental Biology

Wnt inhibitors secreted by the organizer are Dickkopf, Cerberus, Frzb & IGF

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#Id: 7188

#Unit 5. Developmental Biology

Two organizer proteins, inhibt Wnt proteins during gastrulation Tiki and Notum 

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#Unit 5. Developmental Biology

Brain formation requires,  inhibiting both the Wnt and BMP pathways.

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#Id: 7190

#Unit 5. Developmental Biology

IGFs and FGFs in the anterior region, Initiate the receptor tyrosine kinase (RTK) signalling inhibit BMPs and Wnts pathways

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#Unit 5. Developmental Biology

Nodal protein establishes left-right polarity, By activating Pitx2 on the left side

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#Unit 5. Developmental Biology

Antigen pieces are held within the binding groove of a cell surface protein called the major histocompatibility complex (MHC) molecule which recognized by T cell