APC/C core is organized into three modules: 

1. a scaffold module 

2. a catalytic module

3. a substrate recognition module

TLS Online TPP Program

#Id: 2367

#Unit 5. Developmental Biology

Zeta neoblasts give rise to epidermal cell fates through a prog-1-positive postmitotic precursor state.

TLS Online TPP Program

#Id: 2368

#Unit 5. Developmental Biology

Loss of the zeta population 

Epidermal cell types do not fully regenerate in the absence of zeta neoblasts, the remaining neoblasts (likely sigma) and their derived cell types are unaffected.

TLS Online TPP Program

#Id: 2369

#Unit 5. Developmental Biology

In regenerating planaria, Wnt/β-catenin functions to establish anterior-posterior polarity.

TLS Online TPP Program

#Id: 2370

#Unit 5. Developmental Biology

In planaria, Wnts functioning through β-catenin promotes tail development while repressing head regeneration

TLS Online TPP Program

#Id: 2371

#Unit 5. Developmental Biology

In regenerating planaria, β-catenin is activated in the posterior-facing blastema, which generates a tail.

TLS Online TPP Program

#Id: 2372

#Unit 5. Developmental Biology

 In planarian regeneration, an anterior polarity is dependent on repression of Wnt signaling, & allows head formation.