APC/C core is organized into three modules: 

1. a scaffold module 

2. a catalytic module

3. a substrate recognition module

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#Unit 5. Developmental Biology

Dictyostelia (social amoebas)

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#Unit 5. Developmental Biology

Dictyostelium can utilize one of three survival strategies when food starvation-

Microcyst formation, favoured in dark & wet conditions, or ammonia levels are high.

Zygote formation, favoured in dark & wet conditions, & is triggered by ethylene produced by the cells. 

Cell aggregation & differentiation

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#Unit 5. Developmental Biology

Cell Aggregation & Differentiation is common to all Dictyostelids.

It consists of an interconnected programme of cell movement and cell differentiation.

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#Unit 5. Developmental Biology

During growth, unicellular D. discoideum monitor their cell density relative to that of their bacterial food source by secreting a glycoprotein called prestarvation factor at a constant rate.

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#Unit 5. Developmental Biology

When the ratio of PSF relative to that of bacteria exceeds a certain threshold, cells stop proliferating and initiate the expression of genes that are required for their aggregation.

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#Unit 5. Developmental Biology

Early on during aggregation, gene expression requires the activity of cAMP-dependent protein kinase.