TLS Online TPP Program

#Id: 8646

#Unit 2. Cellular Organization

One of the important substrates of the G1/S phase cyclin-CDK complexes is Cdh1.

TLS Online TPP Program

#Id: 8648

#Unit 2. Cellular Organization

During exit from mitosis and G1, 

Cdh1 is de-phosphorylated and APC/Ccdh1 is active.

TLS Online TPP Program

#Id: 8649

#Unit 2. Cellular Organization

During S phase and mitosis, 

Cdh1 is phosphorylated, Cdh1 dissociates from APC/C, and APC/C becomes inactive.

TLS Online TPP Program

#Id: 8650

#Unit 2. Cellular Organization

G1/S phase CDKs phosphorylate Cdh1 at the 

G1-S phase transition

TLS Online TPP Program

#Id: 8651

#Unit 2. Cellular Organization

S phase cyclin-CDK accumulates in late G1 , they are immediately inactivated by binding of a CKI called Sic1

TLS Online TPP Program

#Id: 8652

#Unit 2. Cellular Organization