TLS Online TPP Program

#Id: 8517

#Unit 2. Cellular Organization

Other proteins function with dynein & involved in regulating the activity of dynein during brain development:

LIS1 and NudE

TLS Online TPP Program

#Id: 8518

#Unit 2. Cellular Organization

Defects in LIS1 

Miller-Dieker lissencephaly

means “smooth brain”

TLS Online TPP Program

#Id: 8519

#Unit 2. Cellular Organization

TLS Online TPP Program

#Id: 8520

#Unit 2. Cellular Organization

Post-translational modifications of tubulin:

Lysine acetylation

Detyrosylation

Polyglutamylation

Polyglycylation

TLS Online TPP Program

#Id: 8521

#Unit 2. Cellular Organization

Lysine acetylation & Detyrosylation are found only on α-tubulin and are absent from β-tubulin.

TLS Online TPP Program

#Id: 8522

#Unit 2. Cellular Organization

Lysine acetylation 

ε-amino group of a specific lysine of α-tubulin

Microtubules are stabilized against breakage (centrioles, basal bodies, & primary cilia)