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TLS Online TPP Program

#Id: 8930

If the DNA damage is severe, p21 can cause the cells to senesce or p53 can induce apoptosis.

#Unit 2. Cellular Organization #CELL CYCLE #Part B Pointers
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TLS Online TPP Program

#Id: 9471

#Unit 4. Cell Communication and Cell Signaling

STAT5 becomes activated in erythroid progenitor cells and induces expression of the protein Bcl-xL.
TLS Online TPP Program

#Id: 9472

#Unit 4. Cell Communication and Cell Signaling

Two mechanisms for terminating cytokine signaling:
1. Short-term regulation: SHP1
2. Long-term regulation: SOCS proteins
TLS Online TPP Program

#Id: 9473

#Unit 4. Cell Communication and Cell Signaling

SHP1 a phosphotyrosine phosphatase, contains:
SH2 domain  & Phosphatase domain
TLS Online TPP Program

#Id: 9474

#Unit 4. Cell Communication and Cell Signaling

SHP1 
Binding of an SH2 domain to a phosphotyrosine in the activated receptor unmasks its phosphatase catalytic site
TLS Online TPP Program

#Id: 9475

#Unit 4. Cell Communication and Cell Signaling

SHP1 causes removal of the phosphate from tyrosine in the activation loop of JAK2 & inactivates the JAK kinase.
TLS Online TPP Program

#Id: 9476

#Unit 4. Cell Communication and Cell Signaling

SOCS proteins 
expression is induced by the STAT5 in erythroid progenitor cells, inhibit or permanently terminate signaling over longer periods