TLS Online TPP Program

#Id: 1337

#Unit 4. Cell Communication and Cell Signaling

All RTKs have a cytosolic domain with protein tyrosine kinase activity

TLS Online TPP Program

#Id: 1338

#Unit 4. Cell Communication and Cell Signaling

The EGFR specifically binds EGF in a lock-and-key type of mechanism.

TLS Online TPP Program

#Id: 1339

#Unit 4. Cell Communication and Cell Signaling

The function of a growth factor-  stabilize receptor dimerization

TLS Online TPP Program

#Id: 1340

#Unit 4. Cell Communication and Cell Signaling

HER1 & HER4, can form stable homodimers after binding a growth factor.

TLS Online TPP Program

#Id: 1341

#Unit 4. Cell Communication and Cell Signaling

HER2 can signal only by forming heterodimers with ligand-bound HER1, HER3, or HER4

TLS Online TPP Program

#Id: 1342

#Unit 4. Cell Communication and Cell Signaling

HER3 lacks a functional kinase domain