No matter how it is born, a new gene starts its life as a single copy in the population.

As with any new mutation, by far the most likely outcome is that it will be lost by random drift or selection over the next few generations

TLS Online TPP Program

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#Unit 2. Cellular Organization

MARs are AT rich heterochromatic regions which contains cis-acting sites that regulate transcription, 5’ introns, and a recognition site for topoisomerase II is usually present in the MAR.

TLS Online TPP Program

#Id: 487

#Unit 2. Cellular Organization

Presence of topoisomerase II binding sites shows high degree of negative supercoiling is usually present in the MAR.

TLS Online TPP Program

#Id: 488

#Unit 2. Cellular Organization

(MARs) also called scaffold attachment regions (SARs), or S/MARs in case of metaphase chromosome as the same sequences appear to attach to the protein substructure in both metaphase and interphase cells.

TLS Online TPP Program

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#Unit 2. Cellular Organization

In interphase nuclei, this underlying proteinaceous structure changes its organization to occupy the entire nucleus; during interphase the structure is referred to as the matrix rather than the scaffold.

TLS Online TPP Program

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#Unit 2. Cellular Organization

S/MARs is a DNA sequence which binds to base structure called scaffold.

TLS Online TPP Program

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#Unit 2. Cellular Organization

If histones are depleted from a metaphase chromosome and viewed under a transmission electron microscope shows SCAFFOLD.