TLS Online TPP Program

#Id: 7941

#Unit 2. Cellular Organization

The translocon was first identified through mutations in the yeast gene encoding a protein called Sec61α

TLS Online TPP Program

#Id: 7942

#Unit 2. Cellular Organization

TLS Online TPP Program

#Id: 7943

#Unit 2. Cellular Organization

Classes of ER membrane proteins

TLS Online TPP Program

#Id: 7944

#Unit 2. Cellular Organization

Membrane and soluble secretory proteins synthesized on the rough ER undergo four principal modifications before they reach their final destinations: 

(1) Glycosylation in the ER and Golgi complex

(2) Formation of disulfide bonds in the ER

(3) Proper folding of polypeptide chains and assembly of multisubunit proteins in the ER

(4) Specific proteolytic cleavages in the ER, Golgi complex, and secretory vesicles

TLS Online TPP Program

#Id: 7945

#Unit 2. Cellular Organization

Glycoproteins

Proteins with attached carbohydrates

TLS Online TPP Program

#Id: 7946

#Unit 2. Cellular Organization

O-linked oligosaccharides

Carbohydrate chains in glycoproteins attached to the

hydroxyl group (-OH) in serine and threonine residues