Switching mechanism of monomeric G proteins 

“On” state, switch I and switch II, are bound to the terminal γ phosphate of GTP with the backbone amide groups of conserved T & G.

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If the α helix lies parallel to the direction of the major groove, the straight α helix can contact 4–6 bp before the bases curve out of the plane of the amino acids in the α helix.

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#Unit 1. Molecules and their Interaction Relevant to Biology

The α helices of proteins have an average length of ∼12 residues, which corresponds to more than three helical turns, and a length of ∼18 A.

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α helices are common components of polypeptide chains, they need to be of a certain minimum length of 6 amino acid

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#Unit 1. Molecules and their Interaction Relevant to Biology

The α helices have rotation of 100 degree per amino acid

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Gly is often observed at the C-cap & N cap both positions, Pro at the Ncap and Asp and Glu at N2 and N3.