In response to activation of acetylcholine GPCRs, PLC, and the elevation in cytosolic Ca²+, Nitric oxide is synthesized in endothelial cells.

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#Id: 165

#Unit 5. Developmental Biology

First inducers of the lens are foregut endoderm and cardiac mesoderm that underlie the lens-forming ectoderm during the early and mid gastrula stages.

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#Id: 166

#Unit 5. Developmental Biology

Foregut endoderm and cardiac mesoderm cause the synthesis of the Otx2 transcription factor in the head ectoderm during the late gastrula stage

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#Id: 167

#Unit 5. Developmental Biology

The anterior neural plate produce the next signals, that promotes the synthesis of the Pax6 transcription factor in the anterior ectoderm.

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#Id: 168

#Unit 5. Developmental Biology

Expression of Pax6 protein constitute the competence of the surface ectoderm to respond to the optic vesicle.

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#Id: 169

#Unit 5. Developmental Biology

The optic vesicle secrete two paracrine factors:

 BMP4

 FGF8

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#Id: 170

#Unit 5. Developmental Biology

BMP4 

A protein that is received by the lens cells and induces the production of the Sox transcription factors.