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The TUNEL Assay measures Apoptotically Generated DNA Fragmentation.

#Unit 13. Methods in Biology #Techniques to Analyse Cell Division, DNA Replication, Cell death & Apoptosis #Part B Pointers
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#Unit 5. Developmental Biology


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#Unit 5. Developmental Biology

B-Cell Development


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#Id: 7245

#Unit 5. Developmental Biology

B- cell maturation


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#Unit 5. Developmental Biology

T1 and T2 Transitional B Cells


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#Id: 7247

#Unit 5. Developmental Biology

T1 cells are mIgMhi, mIgD -/lo, CD21-, CD23-, CD24+, and CD93+. 
T2 cells differ from T1 cells in having higher levels of mIgD and in expressing CD21 and CD23. 

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#Unit 5. Developmental Biology

T2 cells also express BAFF-R, the receptor for the B-cell survival factor BAFF, whose expression is dependent on signals received through the BCR. 
As B cells differentiate from the transitional T2 state to full maturity, they raise their levels of mIgD still further, while reducing the expression of mIgM. They also cease to express CD24 and CD93.

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