RI and RII receptors are homodimeric proteins with serine/threonine kinases in their cytosolic domains. 

(RI and RII sufficient to serve as a functional hetero-tetrameric TGF-β receptor)

TLS Online TPP Program

#Id: 440

#Unit 2. Cellular Organization

Runs of two or more AT base pairs facilitate the bending of DNA, while runs of two or more GC base pairs have the opposite effect. 

 

TLS Online TPP Program

#Id: 441

#Unit 2. Cellular Organization

When spaced at about, consecutive AT base pair has 10 bp intervals as consecutive GC base pairs they are offset by 5 bp from runs of AT base pairs.

TLS Online TPP Program

#Id: 442

#Unit 2. Cellular Organization

The nucleosome have 200 bp of DNA with octameric basic proteins into a beadlike structure.

TLS Online TPP Program

#Id: 443

#Unit 2. Cellular Organization

Individual nucleosomes can be obtained by treating chromatin with the endonuclease micrococcal nuclease (MNase), which cuts the DNA at linker DNA.

TLS Online TPP Program

#Id: 444

#Unit 2. Cellular Organization

The high-mobility group (HMG) are nonhistones and may contain Transcriptional Factors.

TLS Online TPP Program

#Id: 445

#Unit 2. Cellular Organization

Core DNA has an invariant length of 146 bp, the minimum length of DNA needed to form a stable monomeric nucleosome, and is relatively resistant to digestion by nucleases- DNA FINGER PRINTING