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TLS Online TPP Program

#Id: 9358

Active type I receptor kinase phosphorylates a Smad

#Unit 4. Cell Communication and Cell Signaling #TGF-β Signaling #Part B Pointers
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TLS Online TPP Program

#Id: 183

#Unit 5. Developmental Biology

Morphogen is a diffusable biochemical molecule that can determine the fate of a cell by its concentration.
TLS Online TPP Program

#Id: 184

#Unit 5. Developmental Biology

Morphogens can be:
Transcription factors
Paracrine factors
TLS Online TPP Program

#Id: 185

#Unit 5. Developmental Biology

A morphogen specifies cells in a quantitative (“more or less”) manner.
TLS Online TPP Program

#Id: 186

#Unit 5. Developmental Biology

A morphogenetic determinant specifies cells in a qualitative (“present or absent”) way.
TLS Online TPP Program

#Id: 187

#Unit 5. Developmental Biology

In the frog (Xenopus laevis)
A gradient of the paracrine factor activin (a morphogen), causes concentration-dependent expression differences of two genes in unspecified cells.
TLS Online TPP Program

#Id: 188

#Unit 5. Developmental Biology

At high concentrations (about 300 molecules/cell), activin induced expression of the goosecoid gene and instructed the cell to become the frog’s dorsal-most structures.