Ligand binding triggers a conformational change in the JAKs & they phosphorylate each other on a critical tyrosine in the activation loop which greatly enhances kinase activity

TLS Online TPP Program

#Id: 4777

#Unit 5. Developmental Biology

Wnt signaling cascade is to downregulate the expression of the pop-1 gene in the EMS daughter destined to become the E cell.

TLS Online TPP Program

#Id: 4778

#Unit 5. Developmental Biology

If the P2 cell is removed at the early 4-cell stage, the EMS cell will divide into two MS cells, and no endoderm will be produced.

TLS Online TPP Program

#Id: 4779

#Unit 5. Developmental Biology

In pop-1-deficient embryos, both EMS daughter cells become E cells.

TLS Online TPP Program

#Id: 4780

#Unit 5. Developmental Biology

Wnt pathway is critical in establishing the anterior-posterior axis of C. elegans.

TLS Online TPP Program

#Id: 4781

#Unit 5. Developmental Biology

The P2 cell is also critical in giving the signal that distinguishes ABp from its sister, ABa

TLS Online TPP Program

#Id: 4782

#Unit 5. Developmental Biology

ABa gives rise to neurons, hypodermis, & anterior pharynx cells ABp makes only neurons and hypodermal cells