In resting state,  the activation loop is not phosphorylated and assumes a conformation that blocks kinase activity.

In insulin receptor, it prevents binding of ATP. 

In FGF receptor, it prevents binding of substrate.

TLS Online TPP Program

#Id: 7781

#Unit 2. Cellular Organization

A structural motif repeated several times within the Y-complex is closely related to a structure found in the COPII proteins that drive the formation of coated vesicles within cells.

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#Id: 6851

#Unit 3. Fundamental Processes

SANT-domain-containing proteins interact preferentially with unmodified histone tails.

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#Id: 4780

#Unit 5. Developmental Biology

Wnt pathway is critical in establishing the anterior-posterior axis of C. elegans.

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#Id: 905

#Unit 13. Methods in Biology

Hydrodynamically focused stream separate cells in single file

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#Id: 6132

#Unit 3. Fundamental Processes