Kinase domains typically contain two regions:

N and C lobes

TLS Online TPP Program

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#Unit 4. Cell Communication and Cell Signaling

Direct-carcinogens includes:

Ethylmethane sulfonate (EMS)

Dimethyl sulfate (DMS)

Nitrogen mustards

TLS Online TPP Program

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#Unit 4. Cell Communication and Cell Signaling

Indirect-acting carcinogens 

Relatively unreactive compounds that become modified to more reactive forms by cellular cytochrome P-450 enzymes

TLS Online TPP Program

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#Unit 4. Cell Communication and Cell Signaling

Benzo(a)pyrene

(found in cigarette smoke & coal tar) undergoes metabolic activation by cytochrome P-450 in the lungs to form a potent mutagen

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#Unit 4. Cell Communication and Cell Signaling

P-450 enzymes, modify benzo(a)pyrene in a series of reactions, producing 7,8-diol-9,10-epoxide, a highly potent mutagenic species

TLS Online TPP Program

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#Unit 4. Cell Communication and Cell Signaling

TLS Online TPP Program

#Id: 10440

#Unit 4. Cell Communication and Cell Signaling

7,8-diol-9,10-epoxide is responsible for cancer development forms an adduct with guanine: 

(+)-trans-anti-B(a)P-N2-dG