c-Cbl contains: 

a domain that binds directly to phosphorylated EGF receptors

a RING finger domain, which recruits ubiquitin-conjugating enzymes and mediates transfer of ubiquitin to the receptor

TLS Online TPP Program

#Id: 8581

#Unit 2. Cellular Organization

B-type lamins - expressed in essentially all cells (primordial lamin proteins)

lamins A and C - developmentally regulated

TLS Online TPP Program

#Id: 8582

#Unit 2. Cellular Organization

Lamins B are post-translationally prenylated, which helps them associate with the inner nuclear envelope membrane.

TLS Online TPP Program

#Id: 8583

#Unit 2. Cellular Organization

Lamins 

contribute to genome organization as well as to the rigidity of the nucleus through linkages to the

cytoskeleton involving proteins with SUN and KASH domains

TLS Online TPP Program

#Id: 8584

#Unit 2. Cellular Organization

TLS Online TPP Program

#Id: 8585

#Unit 2. Cellular Organization

Emerin

lamin-binding membrane protein of the inner nuclear envelope

TLS Online TPP Program

#Id: 8586

#Unit 2. Cellular Organization

Inside the nucleus, SUN proteins bind to the nuclear lamina or chromosomes.