Constitutively active Ras proteins (RasD) 

Replacement of the normal glycine 12 with any other amino acid (except proline) blocks the functional binding of GAP proteins and in essence “locks” Ras in the active GTP-bound state.

TLS Online TPP Program

#Id: 8648

#Unit 2. Cellular Organization

During exit from mitosis and G1, 

Cdh1 is de-phosphorylated and APC/Ccdh1 is active.

TLS Online TPP Program

#Id: 8649

#Unit 2. Cellular Organization

During S phase and mitosis, 

Cdh1 is phosphorylated, Cdh1 dissociates from APC/C, and APC/C becomes inactive.

TLS Online TPP Program

#Id: 8650

#Unit 2. Cellular Organization

G1/S phase CDKs phosphorylate Cdh1 at the 

G1-S phase transition

TLS Online TPP Program

#Id: 8651

#Unit 2. Cellular Organization

S phase cyclin-CDK accumulates in late G1 , they are immediately inactivated by binding of a CKI called Sic1

TLS Online TPP Program

#Id: 8652

#Unit 2. Cellular Organization

TLS Online TPP Program

#Id: 8653

#Unit 2. Cellular Organization

Degradation of Sic1 is induced by its phosphorylation by G1/S phase CDKs.