Ligand-induced receptor activation,

Concentration of PI 3-phosphates rises

PH domain of PKB binds to PI 3-phosphates

TLS Online TPP Program

#Id: 8903

#Unit 2. Cellular Organization

Chromosome compaction involving progressive chromosome looping:

During prophase, condensin II binds DNA and extrudes large loops

In prometaphase, condensin I forms additional loops nested within the loops formed by condensin II

TLS Online TPP Program

#Id: 8904

#Unit 2. Cellular Organization

TLS Online TPP Program

#Id: 8905

#Unit 2. Cellular Organization

Most of the cohesins along the chromosome arms are removed from chromosomes during prophase, mediated by phosphorylation of cohesins by Plk1 & Aurora B kinase.

TLS Online TPP Program

#Id: 8906

#Unit 2. Cellular Organization

TLS Online TPP Program

#Id: 8907

#Unit 2. Cellular Organization

Centromere associated cohesins are specifically protected from phosphorylation dependent removal by protein phosphatase 2A

TLS Online TPP Program

#Id: 8908

#Unit 2. Cellular Organization

Phosphatase is recruited to centromeric by the Shugoshin family of proteins