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TLS Online TPP Program

#Id: 9686

Fat and muscle cells express large amounts of the insulin-responsive glucose transporter GLUT4


#Unit 4. Cell Communication and Cell Signaling #Insulin #Part B Pointers
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TLS Online TPP Program

#Id: 6393

#Unit 2. Cellular Organization

The E. coli trp operon contains the 5 genes Trp-EDCBA for the anabolic enzymes to make the tryptophan.
TLS Online TPP Program

#Id: 6394

#Unit 2. Cellular Organization

Major enzyme is Tryptophan Synthase
TLS Online TPP Program

#Id: 6395

#Unit 2. Cellular Organization

Major enzyme is Tryptophan Synthase whose activity is reduced when trp concentration is high
TLS Online TPP Program

#Id: 6396

#Unit 2. Cellular Organization

Trp operon is negatively regulated by two ways
 Repression
Attenuation
TLS Online TPP Program

#Id: 6397

#Unit 2. Cellular Organization

Why is this extra control of two layers on trp operon needed?  The answer probably lies in the fact that repression of the trp operon is weak—much weaker.
TLS Online TPP Program

#Id: 6398

#Unit 2. Cellular Organization

Repression-Trp aporepressor dimer binds high tryptophan, changes conformation with high affinity for trp operator

Tryptophan is a corepressor