Nurturing Life Sciences
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#Unit 5. Developmental Biology
The “default fate” of the ectoderm is to become neural tissue
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The ectoderm is induced to become epidermal tissue by BMPs
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Siamois and Twin inducing the activation of the neuroepithelium genes – Foxd4 and Sox11
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BMP inhibitors secreted by the organizer are-Noggin, Chordin, Follistatin & Norrin
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Noggin binds to BMP4 and BMP2 and inhibits their binding to receptors