Leishmaniasis

Leishmania is a flagellated protozoan that lives in the phagosomes of macrophages and is transmitted by sand flies.

TLS Online TPP Program

#Id: 2934

#Unit 3. Fundamental Processes

oriC is hemimethylated and remains in that condition for approximately 13 minutes.

TLS Online TPP Program

#Id: 2935

#Unit 3. Fundamental Processes

SeqA binds to hemimethylated DNA more strongly than to fully methylated DNA.

TLS Online TPP Program

#Id: 2936

#Unit 3. Fundamental Processes

Deletion of dat causes initiation to occur more frequently. This significantly increases the amount of DnaA available to the origin.

TLS Online TPP Program

#Id: 2937

#Unit 3. Fundamental Processes

DnaA is provided by its response to phospholipids. Phospholipids promote the exchange of ATP with ADP bound to DnaA.

TLS Online TPP Program

#Id: 2938

#Unit 3. Fundamental Processes

While DnaA has a weak intrinsic activity that converts the ATP to ADP, this is enhanced by a factor termed Hda.

TLS Online TPP Program

#Id: 2939

#Unit 3. Fundamental Processes

Hda recruited, it acts to switch offDnaA, preventing a second round of replication.