Resistance to leishmaniasis correlates well with the production of IFN-ϒ and the development of a TH1 response.

Strains of mice that are naturally resistant to Leishmania develop a TH1 response and produce IFN-ϒ upon infection. 

TLS Online TPP Program

#Id: 10558

#Unit 4. Cell Communication and Cell Signaling

tBid fragment binds to Bcl-2 on the outer mitochondrial membrane, leading to the dissociation of Bak and Bax and release of cytochrome c into the cytosol

TLS Online TPP Program

#Id: 10559

#Unit 4. Cell Communication and Cell Signaling

In cells lacking functional caspase-8 or FADD, TNFα

triggers an alternative pathway, necroptosis.

TLS Online TPP Program

#Id: 10560

#Unit 4. Cell Communication and Cell Signaling

TLS Online TPP Program

#Id: 10561

#Unit 4. Cell Communication and Cell Signaling

Necroptosis pathway triggered by activation of RIPK1 kinase.

TLS Online TPP Program

#Id: 10562

#Unit 4. Cell Communication and Cell Signaling

Activated RIPK1 forms multiprotein complexes via its RHIM domain with the kinase RIPK3, and RIPK3 becomes activated by phosphorylation

TLS Online TPP Program

#Id: 10563

#Unit 4. Cell Communication and Cell Signaling

Active RIPK3 phosphorylates the kinase-like domain of the MLKL protein