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TLS Online TPP Program

#Question id: 1034

A new drug is developed that targets and binds to the lipid A portion of LPS from Gram negative bacterial cells. This drug shows a high degree of activity and binding in a test tube setting against purified lipid A. Based on this information,

#Unit 4. Cell Communication and Cell Signaling

  1. we should fast track this drug and get it out to physicians immediately to help prevent toxic/septic shock in humans.

  2. we should do some animal testing with whole Gram-negative cells and the drug before we jump to any conclusions.

  3. we should next proceed by moving to testing in a test tube using whole Gram-negative cells to see if it binds with the same strength.

  4. we should abandon the drug entirely. Binding to lipid A won't kill the bacteria, so the drug is useless to develop further. It wouldn't help humans who have septic shock at all.

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TLS Online TPP Program

#Question id: 5648

#Unit 5. Developmental Biology

Use the following information to answer the question. In order to test how sea urchin sperm bind to eggs, scientists isolated the egg receptor protein that binds to the sperm acrosomal protein called bindin. Plastic beads were coated with egg receptor for bindin (ERB1) from eggs of the sea urchin Strongylocentrotus purpuratus, and then the beads mixed with sperm from S. purpuratus or from the related species, S. franciscanus. The researchers counted how many sperm were bound to each bead. The results are shown in the graph below. Treatments:

A: S. purpuratus sperm mixed with S. purpuratus ERB1 beads

B: S. purpuratus sperm mixed with beads containing no ERB1 protein

C: S. franciscanus sperm mixed with S. purpuratus ERB1 beads

D: S. franciscanus sperm mixed with beads containing no ERB1 protein

 What is a broader implication from the observations of the experiment?
TLS Online TPP Program

#Question id: 32425

#Unit 2. Cellular Organization

Which of the following elongated protein binds along the groove of the actin filament helix?
TLS Online TPP Program

#Question id: 14779

#Unit 13. Methods in Biology

In a certain college, 4% of the men and 1% of the women are taller than 1.8m. Further 60% of the students are woman. If a student is selected at random and is taller than 1.8m, the probability that the student is women is
TLS Online TPP Program

#Question id: 12856

#General Aptitude

The length and breadth of a rectangular field are in the ratio of 3 : 2. If the perimeter of the field is 80m, its breadth (in metres) is :
TLS Online TPP Program

#Question id: 3365

#Unit 11. Evolution and Behavior

Consider a population of 10,000 individuals, of which 2500 are homozygotes (PP) and 3000 are heterozygotes (Pp) genotype. The frequency of allele p in the population is