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TLS Online TPP Program

#Question id: 1034

A new drug is developed that targets and binds to the lipid A portion of LPS from Gram negative bacterial cells. This drug shows a high degree of activity and binding in a test tube setting against purified lipid A. Based on this information,

#Unit 4. Cell Communication and Cell Signaling

  1. we should fast track this drug and get it out to physicians immediately to help prevent toxic/septic shock in humans.

  2. we should do some animal testing with whole Gram-negative cells and the drug before we jump to any conclusions.

  3. we should next proceed by moving to testing in a test tube using whole Gram-negative cells to see if it binds with the same strength.

  4. we should abandon the drug entirely. Binding to lipid A won't kill the bacteria, so the drug is useless to develop further. It wouldn't help humans who have septic shock at all.

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TLS Online TPP Program

#Question id: 12511

#Unit 8. Inheritance Biology

In this pedigree I 1 and II 2 have Becker muscular dystrophy which shows X-linked recessive inheritance. III 2 has oculocutaneous albinism which shows autosomal recessive inheritance with an incidence in the general population of 1 in 10 000. The disease status for both Becker muscular dystrophy and oculocutaneous albinism is unknown for IV 1 and IV 2.
What is the probability that IV 2 will be affected with oculocutaneous albinism?
TLS Online TPP Program

#Question id: 15003

#Unit 8. Inheritance Biology

Laurie met her husband Jim at a support group for families dealing with PKU (phenylketonurea), a recessive genetic disorder. Laurie and Jim both have one sister who is affected with PKU and no other family history of the disorder. They come to you as a genetic counselor to ask what their risk is of having an affected child. What do you tell them?
TLS Online TPP Program

#Question id: 15004

#Unit 8. Inheritance Biology

Which of the following statements about a pedigree would be most definitive in determining a recessive pattern of inheritance?
TLS Online TPP Program

#Question id: 15005

#Unit 8. Inheritance Biology

You identify a previously unidentified plant species and decide to study its genetics. You establish true breeding strains for leaf shape (longer than wide vs equal length and width) and flower color (white vs. yellow). When you perform a dihybrid cross with these strains, you find that your results are very different than those predicted by a 9:3:3:1 ratio. You calculate a chi square and get a p value of less than 0.0001. Which of the following statements is most accurate based on this observation?
TLS Online TPP Program

#Question id: 15117

#Unit 8. Inheritance Biology

In any population of 10000, in which 100 females were affected from x-linked recessive disorder. What will be the carrier frequency for this x-linked recessive disorder.
TLS Online TPP Program

#Question id: 15118

#Unit 8. Inheritance Biology

In dominant disorder only normal/affected individuals are appeared in population then what will be the correct expression of Hardy-Weinberg principle