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TLS Online TPP Program

#Question id: 1034

A new drug is developed that targets and binds to the lipid A portion of LPS from Gram negative bacterial cells. This drug shows a high degree of activity and binding in a test tube setting against purified lipid A. Based on this information,

#Unit 4. Cell Communication and Cell Signaling

  1. we should fast track this drug and get it out to physicians immediately to help prevent toxic/septic shock in humans.

  2. we should do some animal testing with whole Gram-negative cells and the drug before we jump to any conclusions.

  3. we should next proceed by moving to testing in a test tube using whole Gram-negative cells to see if it binds with the same strength.

  4. we should abandon the drug entirely. Binding to lipid A won't kill the bacteria, so the drug is useless to develop further. It wouldn't help humans who have septic shock at all.

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TLS Online TPP Program

#Question id: 17995

#Unit 8. Inheritance Biology

Consider a heritable autosomal disease with an incidence in the population of 1 per thousand. On average, individuals with the disease have 80% as many children as the population average. In answering the various parts of this question, assume that mating is random. What mutation rate would be required to maintain the observed incidence of the disease in the population if the disease is recessive?
TLS Online TPP Program

#Question id: 17996

#Unit 8. Inheritance Biology

Consider a heritable autosomal disease with an incidence in the population of 1 per thousand. On average, individuals with the disease have 80% as many children as the population average. In answering the various parts of this question, assume that mating is random. Now assume that the mutation rate is zero, that the disease is recessive, and that the disease allele is maintained in the population by heterozygote advantage. Calculate the heterozygote advantage,
TLS Online TPP Program

#Question id: 17997

#Unit 14. Methods in Biology

In RNA isolation, for protein free solution what will be the ratio at  nm
TLS Online TPP Program

#Question id: 17998

#Unit 14. Methods in Biology

Eukaryotic mRNA species are isolated by using
TLS Online TPP Program

#Question id: 18001

#Unit 9. Evolution & Diversity of Life Forms

Where in an angiosperm would you find a megasporangium? 

TLS Online TPP Program

#Question id: 18002

#Unit 9. Evolution & Diversity of Life Forms

What is the greatest threat to plant diversity?