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TLS Online TPP Program

#Question id: 1034

A new drug is developed that targets and binds to the lipid A portion of LPS from Gram negative bacterial cells. This drug shows a high degree of activity and binding in a test tube setting against purified lipid A. Based on this information,

#Unit 4. Cell Communication and Cell Signaling

  1. we should fast track this drug and get it out to physicians immediately to help prevent toxic/septic shock in humans.

  2. we should do some animal testing with whole Gram-negative cells and the drug before we jump to any conclusions.

  3. we should next proceed by moving to testing in a test tube using whole Gram-negative cells to see if it binds with the same strength.

  4. we should abandon the drug entirely. Binding to lipid A won't kill the bacteria, so the drug is useless to develop further. It wouldn't help humans who have septic shock at all.

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TLS Online TPP Program

#Question id: 15004

#Unit 8. Inheritance Biology

Which of the following statements about a pedigree would be most definitive in determining a recessive pattern of inheritance?
TLS Online TPP Program

#Question id: 15005

#Unit 8. Inheritance Biology

You identify a previously unidentified plant species and decide to study its genetics. You establish true breeding strains for leaf shape (longer than wide vs equal length and width) and flower color (white vs. yellow). When you perform a dihybrid cross with these strains, you find that your results are very different than those predicted by a 9:3:3:1 ratio. You calculate a chi square and get a p value of less than 0.0001. Which of the following statements is most accurate based on this observation?
TLS Online TPP Program

#Question id: 15006

#Unit 8. Inheritance Biology

Which of the following is not a mechanism for sex determination?
TLS Online TPP Program

#Question id: 15007

#Unit 8. Inheritance Biology

You set up a cross between true breeding wild type male fruit flies and true breeding female flies with a yellow body color. You notice in the F1 generation that half the flies, specifically all the males, have yellow body color while the females are wild type (gray). Which of the following explanations is the most likely?
TLS Online TPP Program

#Question id: 15008

#Unit 8. Inheritance Biology

You have a white eyed, male fruit fly with vestigial wings and a wild type female known to be heterozygous for both traits. You know that vestigial is located on an autosome. What is the probability that a mating between these two flies will generate a female offspring with vestigial wings and white eyes?
TLS Online TPP Program

#Question id: 15009

#Unit 8. Inheritance Biology

A mutation in which most of the protein coding sequence of the gene is removed is most likely to be which type of allele?