Particular receptor tyrosine kinases (RTKs) that promote excessive cell division are found at high levels in various cancer cells. HER2 is an RTK that is present at excessively high levels in some breast cancer cells. Herceptin is a protein that binds to HER2 and inhibits cell division. Herceptin may be an effective treatment for breast cancer treatment under which of the following conditions?

TLS Online TPP Program

#Question id: 23113

#Unit 2. Cellular Organization

Chromatin on digestion with Mnase can be result on centrifugation and electrophoresis, on sedimentation the following result is obtained 

TLS Online TPP Program

#Question id: 23114

#Unit 2. Cellular Organization

What is the minimum length to stabilize nucleosome 

TLS Online TPP Program

#Question id: 23115

#Unit 2. Cellular Organization

The assay which is used in DNA foot-printing to identify the nitrogenous base sequences

TLS Online TPP Program

#Question id: 23116

#Unit 2. Cellular Organization

Choose the correct statement 

a. The nucleosome is a disc with DNA organized into 22/3 turns around the core .

b. The nucleosome is a disc with DNA organized into 12/3 turns around the surface.

c. The nucleosome is a disc of 11 nm diameter and 6 nm height.

d. The nucleosome is a cylinder of 6 nm diameter and 11 nm height.

TLS Online TPP Program

#Question id: 23117

#Unit 2. Cellular Organization

Choose the correct statement of the following  

a. The nucleosome consists of approximately equal masses of DNA and histones (including H1). 

b. The four core histones are present in equal amounts in the cell.

c. H1 is half as abundant as the other histones, which is consistent with the finding that only one molecule of H1 can associate with a nucleosome.

d. One turn around the nucleosome takes 80 bp of DNA

TLS Online TPP Program

#Question id: 23118

#Unit 2. Cellular Organization

How many bp distance require to Two points helix may actually be one on another on nucleosome surface.