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TLS Online TPP Program

#Question id: 1244

Which type of experimental evidence shows that the intrinsic GTPase activity of the Gα subunit is important for terminating effector activation?

#Unit 4. Cell Communication and Cell Signaling

  1. A nonhydrolyzable GTP analog that can bind to the Gα subunit but cannot be hydrolyzed by the intrinsic GTPase, thereby activating the effector protein longer upon ligand-induced activation of the receptor. 

  2. A nonhydrolyzable GTP analog causes displacement of GDP with the modified GTP resulting in continuous activation of the receptor because the bound GTP analog cannot be hydrolyzed to GDP.

  3. A dominant active (constant activity) GEF causes stimulation of the effector protein for longer upon ligand-induced activation of the receptor.

  4. A dominant negative (no activity) GEF causes stimulation of the effector protein for longer upon ligand-induced activation of the receptor.

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TLS Online TPP Program

#Question id: 28620

#Unit 2. Cellular Organization

APC/C works with core and substrate-targeting factors, the core is organized into several different modules, except?
TLS Online TPP Program

#Question id: 28621

#Unit 2. Cellular Organization

Substrate-targeting subunits of the APC/C recognize specific sequence motifs on the proteins that the APC/C ubiquitinates. One motif the destruction box or D-box, has the consensus sequence is___
TLS Online TPP Program

#Question id: 28622

#Unit 2. Cellular Organization

What will cause if mutating or deleting the destruction box in mitotic cyclins? 
a) Allows loading of MCM helicases
b) prevented mitotic cyclins ubiquitinylation
c) blocked mitotic cells from exiting mitosis
d) inhibition of re-initiation at origins
TLS Online TPP Program

#Question id: 28623

#Unit 2. Cellular Organization

At which phase of APC/C bound to Cdc20 targets protein for degradation? 
TLS Online TPP Program

#Question id: 28624

#Unit 2. Cellular Organization

Ubiquitin protein-ligases APC/CCdc20  performs various functions such as  
a) Degradation of geminin
b) Degradation of securin
c) Induce degradation of B-type cyclin
d) Allows chromosomal separation
Which of the following is incorrect about APC/CCdc20
TLS Online TPP Program

#Question id: 28625

#Unit 2. Cellular Organization

Ubiquitin protein-ligases APC/CCdh1  performs various functions such as  
a) Degradation of geminin
b) Degradation of securin
c) Induce degradation of B-type cyclin in G1
d) Allows loading of  replicative helicase 
Which of the following is incorrect about APC/CCdh1