TLS Online TPP Program

#Question id: 1246


An SH2-containing protein contains a mutation that changes its binding pocket such that tyrosine and phosphotyrosine bind with equal affinity. As a result, MEK activity:

#Unit 4. Cell Communication and Cell Signaling
  1. decreases due to changes in Raf activation.

  2. decreases due to allosteric inhibition of SH2-domain binding.

  3. increases with ligand binding-induced dimerization.

  4. does not change with receptor dimerization and transautophosphorylation.