TLS Online TPP Program

#Question id: 1261


A FOXO3a mutant in which the three serine residues that are targets for PKB are mutated to alanine then what will be the result?

#Unit 4. Cell Communication and Cell Signaling
  1. Dephosphorylated FOXO3a will be constitutively active and initiates apoptosis even in the presence of activated PKB.

  2. Phosphorylated FOXO3a will be permanently repressed and inhibit apoptosis even in the presence of activated PKB.

  3. Dephosphorylated FOXO3a will be constitutively active and initiates synthesis of anti- apoptotic genes.

  4. Phosphorylated FOXO3a will be constitutively active and inhibits PKB.