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TLS Online TPP Program

#Question id: 1261

A FOXO3a mutant in which the three serine residues that are targets for PKB are mutated to alanine then what will be the result?

#Unit 4. Cell Communication and Cell Signaling

  1. Dephosphorylated FOXO3a will be constitutively active and initiates apoptosis even in the presence of activated PKB.

  2. Phosphorylated FOXO3a will be permanently repressed and inhibit apoptosis even in the presence of activated PKB.

  3. Dephosphorylated FOXO3a will be constitutively active and initiates synthesis of anti- apoptotic genes.

  4. Phosphorylated FOXO3a will be constitutively active and inhibits PKB.

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TLS Online TPP Program

#Question id: 12495

#Unit 8. Inheritance Biology

Haemophilia A is a severe coagulation disorder that shows X-linked recessive inheritance. Red-green colour blindness also shows X-linked recessive inheritance. A man with both haemophilia A and colour blindness is referred for genetic counseling. Assume that his partner is not a carrier of either of these conditions. Which of the following is correct?
TLS Online TPP Program

#Question id: 12496

#Unit 8. Inheritance Biology

A woman who has two brothers and a maternal uncle (her mother's brother) with non-specific X-linked mental retardation is referred for genetic counselling. There are no diagnostic tests available to help determine whether or not she is a carrier. Which of the following is correct?
TLS Online TPP Program

#Question id: 12497

#Unit 8. Inheritance Biology

In this pedigree A and B represent alleles at a marker locus closely linked to the disease locus. Affected individuals are shown as shaded. The disease status in III 1 is unknown. Which of the following is correct?
TLS Online TPP Program

#Question id: 12498

#Unit 8. Inheritance Biology

In this pedigree II 1 is affected with an autosomal recessive disorder. The disease status for II 2 and II 3 is unknown. A and B represent alleles at a locus which is tightly linked to the disease locus with recombination fraction of 0. On the basis of the linked marker genotypes II 2 can be told that: 
TLS Online TPP Program

#Question id: 12499

#Unit 8. Inheritance Biology

On the basis of the linked marker genotypes II 3 can be told that:
TLS Online TPP Program

#Question id: 12500

#Unit 8. Inheritance Biology

In this pedigree II 1 is affected with an autosomal recessive disorder. The disease status for II 2, II 3 and II 4 is unknown. A and B represent alleles at a locus which is tightly linked to the disease locus with recombination fraction of 0. On the basis of the linked markers II 2 can be told that: