TLS Online TPP Program

#Question id: 14739


In heart muscle, activation series of the muscarinic acetylcholine receptor its effector K+ channel via the Gβγ subunit of a Gi protein.
a. Binding of acetylcholine triggers activation of the Gαi subunit and its dissociation from the Gβγ subunit in the usual way. 
b. The released Gβγ subunit (rather than Gαi∙GTP) binds to and opens the associated effector protein, a K+ channel. 
b. The increase in K+ permeability hyperpolarizes the membrane, which reduces the frequency of heart muscle contraction. 
d. Activation is terminated when the GTP bound to Gαi is hydrolyzed (by a GAP enzyme that is an intrinsic part of the Gαi subunit) to GDP and Gαi∙GDP recombines with Gβγ.

#Unit 4. Cell Communication and Cell Signaling
  1. a-b-c-d
  2. b-c-d-a
  3. c-b-a-d
  4. b-c-a-d